Poloxamer 407, nf is a national formulary approved surfactant that finds utility because of its amphiphilic structure. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. This study is aimed to investigate the applicability of poloxamer 407 p407 and 188 p188. The aim of this study was to compare the effect of polyvinylpyrrolidone k30 pvp and poloxamer 188 plx as carrier in solid dispersion formulations of celecoxib clx. Quantitation of poloxamers in pharmaceutical formulations.
Assessment of transdermal penetration enhancement by. Poloxamer 407 was a gift sample from basf corporation, mumbai. The ease of production, the stability at 4 c or at room temperature and the low cost of the formulation, when compared to the phospholipids used in the liposomal formulations, are attractive conditions. The surfactant poloxamer188 protects against glutamate toxicity in the rat brain david m. In this study, a new heparinpoloxamer 188 conjugate hp was synthesized and its physicochemical.
Poloxamers are also known by the trade names synperonics. They make this highlyefficient intermediate, used in many types of. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj. You can find detailed information on our product range by looking up your industry or using our product finder. Poloxamer 188 and poloxamer 407 stock standards were prepared by dissolving 200 mg of poloxamer in 100 ml of water to make 2. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Poloxamer 188 chemical information, properties, structures, articles, patents and more chemical data. Stripped poloxamer place about 500 g of poloxamer 124 into a suitable 3neck, roundbottom flask equipped with a stirrer, a thermometer, a vacuum outlet, and a heating mantle. Poloxamer 188, european pharmacopoeia ep reference standard. They are also used in topical dosage forms and rectal suppositories. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. The principle on which the 3d printer is based is to lay a filament of.
Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in. Btc is basfs european sales organization for speciality chemical distribution. There is a possibility that this would work better than injections. You will then be directed to your local website with complete product information for your local needs. Poloxamer also known as poloxalene and pluronic is a family of syntheic block copolymers of ethylene oxide and propylene oxide. Basf engineering plastics offer decisive advantages over established metal structures in many areas. In this study, a new heparin poloxamer 188 conjugate hp was synthesized and its physicochemical.
Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Poloxamer 407mediated alterations in the activities of enzymes regulating lipid metabolism in rats. Initially, the in vitro antileishmanial activity ic 50 value of ampbm and bampbm empty micelles against stationary promastigotes and amastigoteslike forms of the parasites was. Basf to develop a high purity poloxamer for mast therapeutics. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. A comparative evaluation of poloxamer 407 and oxidized. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamer 407 p407 and 188 p188 were obtained from basf co.
English pdf, 627 kb superb foam with the pu fixed poker from basf. Solutions for the agricultural industry btc europe. Nov 17, 2014 melting point nonproprietry name melting point c poloxamer 124 16 poloxamer 188 5257 poloxamer 237 49 poloxamer 338 57 poloxamer 407 5257 28. Poloxamer hydrogels for biomedical applications mdpi. Poloxamer is a common biopolymer in intradermal drugdelivery. Cas registry number chemical abstracts service 0106392125. Our products support customers in meeting the specific needs of the key plastics markets they serve such as. There are multiple ways to analyze these copolymers to include spectroscopic, chromatography, and titration methods. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. Brochures intermediates for special applications basf. Poloxamer are used for improve the stability of nanoparticle and liposome.
Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada ira j. This section showcases our global product portfolio only. Pdf multiblock poloxamer surfactants suppress aggregation. Pdf synthesis and characterization of poloxamer 188. Despite their wide range of applications, limited analytical techniques have been reported in. Poloxamer 407 pluronic f127 has been applied in a very broad range in biomedical and pharmaceutical industries torchilin et al.
Differential effects of commercialgrade and purified. The only monographed poloxamer that is liquid at room temperature. Poloxamer are used in solid dispersion as solubility enhancer. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. The most versatile and costeffective of the plasticizers, it improves concrete performance with excellent early strength and rheology. Multiblock poloxamer surfactants suppress aggregation of denatured proteins article pdf available in biochimica et biophysica acta 17801. Assessment of transdermal penetration enhancement by topical.
In vitro evaluation of poloxamer in situ forming gels for bedaquiline. Moisture content poloxamers generally contain less than 0. Basf report 2014 pdf download the entire basf report 2014 as a pdf. Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada. It possesses solubilizing, bodying and gelling properties. Learn about poloxamer from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Fagron wants to widen the therapeutic scope of the. In vivo tmax of the im administered poloxamer in situ forming gels was about 6 h and a shortterm. Polyoxyetylenepolyoxypropylene glycol block copolymer. You need more than just a product to solve your challenges.
Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. Basf corporation evaluation of lutrol f grades prill vs. Pluronic grade has thermo reversible gelation property, liquid at room temperature and convert gel at body temperature, so it is used in the control release formulation. The surfactant poloxamer188 protects against glutamate. The range of applications for these intelligent plastic solutions extends far beyond automotive engineering and opens up significant development potential for the solar, construction and water industry. Btc is basf s european sales organization for speciality chemical distribution. Pdf synthesis and characterization of poloxamer 188grafted. Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs.
German pdf, 6 mb english pdf, 6 mb chemistry creates versatility. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. You will then be directed to your local website with complete product information for. Basf has a globally unique portfolio of chemical intermediates for the manufacture of outstandingly versatile polyurethane pur materials, including an extensive range of highperformance catalysts, polyols, additives and solvents. In the present study, a poloxamer 407based amphotericin b ampbcontaining polymeric micelles system ampbm was employed in the treatment of leishmania amazonensisinfected balbc mice. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. The surfactant poloxamer 188 protects against glutamate toxicity in the rat brain david m.
Poloxamerum latin poloxamer german poloxamere french poloxamero spanish generic names. Poloxamer block copolymers are non ionic surfactants available under the. Masterpolyheed is a nonchloride, midrange waterreducing admixture formulated for superior workability and finishing. Poloxamer 407mediated alterations in the activities of. Evacuate the flask carefully at room temperature to a pressure of less than 10 mm of mercury, applying the vacuum slowly to avoid excessive foaming due to entrapped gases.
For you, we combine cuttingedge solutions with established expertise. Poloxamer 407 pluronic f127based polymeric micelles for. It is a surfactant functioning both as cleansing and solubilizing agent. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. You need a variety of highperformance materials, application, engineering. Apr 17, 2020 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Poloxamerbased in situ hydrogels for controlled delivery of. Preparation and characterization of celecoxib solid.
Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. A supercritical fluid extraction process was used to prepare p188p. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. The aim of this study was to compare the effect of polyvinylpyrrolidone k30 pvp and poloxamer188 plx as carrier. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Basf is a leading manufacturer, supplier and innovation partner of plastic additives such as light stabilizers, antioxidants and process stabilizers, as well as other additives for the plastics industry. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407.
Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. Basf maintains a drug master file for poloxamers at the fda and is familiar with. To find technical product information, drawings, and details please use the country locator below and select the region and country of your choice. Apply a maximum of 4 applications per crop per season. P338 and p407 were bought from basf mannheim, germany and peg400 from clariant frankfurt am main, germany. Masterpolyheed nonchloride, midrange waterreducing concrete admixtures. Nov 21, 2012 poloxamer are used in solid dispersion as solubility enhancer. In addition to poloxamer 188 nf, basf also offers comprehensive solutions to the pharmaceutical industry for both small and large molecule formulation needs.
690 638 1466 915 724 280 1032 597 1099 1128 394 1391 437 776 382 71 1486 1369 732 1159 1396 894 1061 83 110 362 749 1211 448 1358 1271 1170 1328 731 1236